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Synlett 1994; 1994(4): 247-249
DOI: 10.1055/s-1994-22813
DOI: 10.1055/s-1994-22813
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© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved.
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data processing and storage.Synthesis of the Southern Hemisphere of Theonellamide F, A Bicyclic Dodecapeptide of Marine Origin
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Publication History
Publication Date:
22 March 2002 (online)
The southern hemisphere S of theonellamide F (1), a bicyclic dodecapeptide form a marine sponge, was synthesized in its protected form 2 by the preparation of the building blocks of the nonproteinogenic amino acids, followed by the construction of the whole molecule utilizing diphenyl phosphorazidate or diethyl phosphorocyanidate as a coupling reagent.